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Volume 219, 2019
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Charge-tuning of glycosaminoglycan-based hydrogels to program cytokine sequestration

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Abstract

Glycosaminoglycan (GAG)-based biohybrid hydrogels of varied GAG content and GAG sulfation pattern were prepared and applied to sequester cytokines. The binding of strongly acidic and basic cytokines correlated with the integral space charge density of the hydrogel, while the binding of weakly charged cytokines was governed by the GAG sulfation pattern.

Graphical abstract: Charge-tuning of glycosaminoglycan-based hydrogels to program cytokine sequestration

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Article information


Submitted
11 Feb 2019
Accepted
22 Feb 2019
First published
22 Feb 2019

Faraday Discuss., 2019,219, 244-251
Article type
Paper

Charge-tuning of glycosaminoglycan-based hydrogels to program cytokine sequestration

U. Freudenberg, P. Atallah, Y. D. P. Limasale and C. Werner, Faraday Discuss., 2019, 219, 244
DOI: 10.1039/C9FD00016J

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