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Issue 44, 2019
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Palladium(ii) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors

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Abstract

New palladium complexes with thiosemicarbazonate ligands derived from pyrene exhibit potent antiproliferative activity against A2780 and cisplatin-resistant A2780Cis human ovarian cancer cells, which is dependent on substituent groups of the thiosemicarbazone ligands. Cellular accumulation and distribution studies confirmed that palladium enters the cell nucleus. DNA and topoisomerase IB studies show that one complex is a potent TopIB inhibitor, with selectivity for cancer versus normal cells.

Graphical abstract: Palladium(ii) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors

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Supplementary files

Article information


Submitted
18 Jun 2019
Accepted
24 Sep 2019
First published
30 Oct 2019

This article is Open Access

Dalton Trans., 2019,48, 16509-16517
Article type
Paper

Palladium(II) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors

C. G. Oliveira, I. Romero-Canelón, M. M. Silva, J. P. C. Coverdale, P. I. S. Maia, A. A. Batista, S. Castelli, A. Desideri, P. J. Sadler and V. M. Deflon, Dalton Trans., 2019, 48, 16509
DOI: 10.1039/C9DT02570G

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