Jump to main content
Jump to site search

Issue 34, 2019
Previous Article Next Article

Multifunctional NaYF4:Yb,Er@PE3@Fe3O4 nanocomposites for magnetic-field-assisted upconversion imaging guided photothermal therapy of cancer cells

Author affiliations

Abstract

Even though various theranostic agents have been exploited for effective cancer therapy over the years, appropriate design and fabrication of theranostic agents with simple composition, convenient preparation, high theranostic efficiency and minimal side effects on non-cancer cells are still urgently needed. Herein, multifunctional NaYF4:Yb,Er@polyelectrolyte (PE3)@Fe3O4 nanocomposites, with upconversion luminescence, superparamagnetism and photothermal performance, are prepared by a layer-by-layer self-assembly technique. Compared with Fe3O4 nanoparticles (NPs), the nanocomposites exhibited nearly 2-fold strong absorption at 808 nm, and thus resulted in an enhanced near-infrared photothermal effect. With the assistance of an external magnetic field, a high sensitivity of upconversion fluorescence imaging and a low cancer cell viability of 13.9% were achieved under 808 nm laser irradiation. It is expected that multifunctional NaYF4:Yb,Er@PE3@Fe3O4 nanocomposites would pave the way toward promoting the clinical applications of theranostic nanomaterials.

Graphical abstract: Multifunctional NaYF4:Yb,Er@PE3@Fe3O4 nanocomposites for magnetic-field-assisted upconversion imaging guided photothermal therapy of cancer cells

Back to tab navigation

Publication details

The article was received on 03 Jun 2019, accepted on 30 Jul 2019 and first published on 30 Jul 2019


Article type: Paper
DOI: 10.1039/C9DT02329A
Dalton Trans., 2019,48, 12850-12857

  •   Request permissions

    Multifunctional NaYF4:Yb,Er@PE3@Fe3O4 nanocomposites for magnetic-field-assisted upconversion imaging guided photothermal therapy of cancer cells

    S. Fu, Y. Ding, T. Cong, X. Yang, X. Hong, B. Yu, Y. Li and Y. Liu, Dalton Trans., 2019, 48, 12850
    DOI: 10.1039/C9DT02329A

Search articles by author

Spotlight

Advertisements