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Issue 20, 2019
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Chemoenzymatic cascade for stilbene production from cinnamic acid catalyzed by ferulic acid decarboxylase and an artificial metathease

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Abstract

We report the preparation of symmetrical stilbene derivatives in a two-step one-pot cascade reaction based on enzymatic decarboxylation of cinnamic acid followed by olefin cross metathesis. Embedment of the metathesis catalyst in a protein scaffold enabled the cascade reaction to symmetric stilbenes and furthermore very efficient removal of metal impurities (<1 ppm in product fraction).

Graphical abstract: Chemoenzymatic cascade for stilbene production from cinnamic acid catalyzed by ferulic acid decarboxylase and an artificial metathease

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Article information


Submitted
18 Jul 2019
Accepted
12 Sep 2019
First published
18 Sep 2019

Catal. Sci. Technol., 2019,9, 5572-5576
Article type
Communication

Chemoenzymatic cascade for stilbene production from cinnamic acid catalyzed by ferulic acid decarboxylase and an artificial metathease

M. A. S. Mertens, D. F. Sauer, U. Markel, J. Schiffels, J. Okuda and U. Schwaneberg, Catal. Sci. Technol., 2019, 9, 5572
DOI: 10.1039/C9CY01412H

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