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Issue 4, 2019
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Biohybrid catalysts for sequential one-pot reactions based on an engineered transmembrane protein

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Abstract

A one-pot cascade reaction sequence to obtain 1,2-diarylethanes from styrenes was developed. The cascade reaction comprises an olefin cross metathesis and a hydrogenation step with two biohybrid catalysts. One biohybrid catalyst is based on the engineered transmembrane protein FhuA harboring a Grubbs–Hoveyda-type ruthenium carbene complex and the other one harbors a rhodium(I) complex. Both active sites are covalently anchored via a modified N-heterocyclic carbene (NHC).

Graphical abstract: Biohybrid catalysts for sequential one-pot reactions based on an engineered transmembrane protein

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Article information


Submitted
29 Oct 2018
Accepted
11 Jan 2019
First published
14 Jan 2019

Catal. Sci. Technol., 2019,9, 942-946
Article type
Communication

Biohybrid catalysts for sequential one-pot reactions based on an engineered transmembrane protein

D. F. Sauer, Y. Qu, M. A. S. Mertens, J. Schiffels, T. Polen, U. Schwaneberg and J. Okuda, Catal. Sci. Technol., 2019, 9, 942
DOI: 10.1039/C8CY02236D

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