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Issue 11, 2019
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Bayesian determination of the effect of a deep eutectic solvent on the structure of lipid monolayers

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Abstract

In this work, we present the first example of the self-assembly of phospholipid monolayers at the interface between air and an ionic solvent. Deep eutectic solvents are a novel class of environmentally friendly, non-aqueous, room temperature liquids with tunable properties, that have wide-ranging potential applications and are capable of promoting the self-assembly of surfactant molecules. We use a chemically-consistent Bayesian modelling of X-ray and neutron reflectometry measurements to show that these monolayers broadly behave as they do on water. This method allows for the monolayer structure to be determined, alongside the molecular volumes of the individual monolayer components, without the need for water-specific constraints to be introduced. Furthermore, using this method we are able to better understand the correlations present between parameters in the analytical model. This example of a non-aqueous phospholipid monolayer has important implications for the potential uses of these solvents and for our understanding of how biomolecules behave in the absence of water.

Graphical abstract: Bayesian determination of the effect of a deep eutectic solvent on the structure of lipid monolayers

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Supplementary files

Article information


Submitted
11 Jan 2019
Accepted
22 Feb 2019
First published
22 Feb 2019

This article is Open Access

Phys. Chem. Chem. Phys., 2019,21, 6133-6141
Article type
Paper

Bayesian determination of the effect of a deep eutectic solvent on the structure of lipid monolayers

A. R. McCluskey, A. Sanchez-Fernandez, K. J. Edler, S. C. Parker, A. J. Jackson, R. A. Campbell and T. Arnold, Phys. Chem. Chem. Phys., 2019, 21, 6133
DOI: 10.1039/C9CP00203K

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