Issue 26, 2019

Competition between folded and extended structures of alanylalanine (Ala-Ala) in a molecular beam

Abstract

We report the gas phase conformational preferences of laser desorbed Ala-Ala dipeptides probed by action spectroscopy using the IRMPD-VUV method. The molecules were internally cooled through collisional cooling in a supersonic jet environment. An IR spectrum was obtained experimentally in the spectral range of 700–1850 cm−1, and subsequently interpreted with the help of quantum chemical calculations. Although theory predicts that folded structures have lower electronic energies and, thus, are more stable at low temperatures compared to their extended (β-strand-like) counterparts, analysis of the experimental data concluded the extended conformer to be the most dominant. An explanation to this observation is discussed in this paper and rationalized in terms of collisional conformer relaxation processes occurring in the supersonic jet molecular beam.

Graphical abstract: Competition between folded and extended structures of alanylalanine (Ala-Ala) in a molecular beam

Supplementary files

Article information

Article type
Paper
Submitted
09 Jan 2019
Accepted
05 Mar 2019
First published
06 Mar 2019
This article is Open Access
Creative Commons BY-NC license

Phys. Chem. Chem. Phys., 2019,21, 14126-14132

Competition between folded and extended structures of alanylalanine (Ala-Ala) in a molecular beam

V. Yatsyna, R. Mallat, T. Gorn, M. Schmitt, R. Feifel, A. M. Rijs and V. Zhaunerchyk, Phys. Chem. Chem. Phys., 2019, 21, 14126 DOI: 10.1039/C9CP00140A

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