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Issue 2, 2019
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Electronic transport in a graphene single layer: application in amino acid sensing

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Abstract

We modeled a type of field-effect transistor device based on graphene for the recognition of amino acids with a potential application in the building of a protein sequencer. The theoretical model used was a combination of density functional theory (DFT) with the non-equilibrium Green's function (NEGF) in order to describe the coherent transport in molecular devices. First, we studied the physisorption of each amino acid on a graphene sheet and we reported the adsorption energy, the adsorption distances, the equilibrium configuration and the charge transfer of ten amino acids that can be considered as representative of all of the amino acids: histidine (His), alanine (Ala), aspartic acid (Asp), tyrosine (Tyr), arginine (Arg), glutamic acid (Glu), glycine (Gly), phenylalanine (Phe), proline (Pro) and lysine (Lys). As a result, significant differences were found in the density of states (DOS) after adsorption and there was a change in the semi-metallic character of the graphene due to the lysine and arginine interactions. Furthermore, we noticed changes in the electrical characteristics of the devices, as the amino acids adsorbed onto the surface of the graphene. The curves of current vs. bias voltage (IVb) display a distinct response for each amino acid, i.e. the IVb curves produce a characteristic footprint for each amino acid. We identified a possible rectification mechanism related to the voltage profile asymmetry, where the amino acids can control the transport characteristics in the device, i.e. Lys and Phe amino acids physisorbed on graphene act as a molecular diode, where electrons can easily flow in one direction and decrease in the other. This may be promising for the prospect of biosensors: graphene could be used as an amino acid detector.

Graphical abstract: Electronic transport in a graphene single layer: application in amino acid sensing

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Article information


Submitted
09 Aug 2018
Accepted
27 Nov 2018
First published
03 Dec 2018

Phys. Chem. Chem. Phys., 2019,21, 597-606
Article type
Paper

Electronic transport in a graphene single layer: application in amino acid sensing

S. J. Rodríguez and E. A. Albanesi, Phys. Chem. Chem. Phys., 2019, 21, 597
DOI: 10.1039/C8CP05093G

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