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Issue 28, 2019
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Template-induced nucleation for controlling crystal polymorphism: from molecular mechanisms to applications in pharmaceutical processing

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Abstract

Over the last two decades, the use of template surfaces to induce heterogeneous crystal nucleation has been explored primarily to address two different goals: first, as an alternative to the conventional seeding technique used for polymorph control and, second, as a technique to promote the nucleation rate in novel crystallisation processes and formulations. The former need conceivably arises due to the risk of crystallising a new polymorph despite pre-seeding the solution with the desired crystal form. In this context, we review ongoing efforts in the research area of template-induced crystallisation, covering both experimental and simulation studies directed towards deeper understanding of the underpinning mechanisms. In addition, we report on the use of template-induced crystal nucleation as a process intensification technology for formulating drug substances and as a technique for enabling nucleation and polymorphic control during continuous manufacturing of active pharmaceutical ingredients.

Graphical abstract: Template-induced nucleation for controlling crystal polymorphism: from molecular mechanisms to applications in pharmaceutical processing

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Publication details

The article was received on 19 Mar 2019, accepted on 15 May 2019 and first published on 16 May 2019


Article type: Highlight
DOI: 10.1039/C9CE00404A
CrystEngComm, 2019,21, 4122-4135

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    Template-induced nucleation for controlling crystal polymorphism: from molecular mechanisms to applications in pharmaceutical processing

    J. V. Parambil, S. K. Poornachary, J. Y. Y. Heng and R. B. H. Tan, CrystEngComm, 2019, 21, 4122
    DOI: 10.1039/C9CE00404A

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