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Issue 100, 2019
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Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition

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Abstract

Here, a reaction-based indicator displacement hydrogel assay (RIA) was developed for the detection of hydrogen peroxide (H2O2) via the oxidative release of the optical reporter Alizarin Red S (ARS). In the presence of H2O2, the RIA system displayed potent biofilm inhibition for Methicillin-resistant Staphylococcus aureus (MRSA), as shown through an in vitro assay quantifying antimicrobial efficacy. This work demonstrated the potential of H2O2-responsive hydrogels containing a covalently bound diol-based drug for controlled drug release.

Graphical abstract: Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition

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Supplementary files

Article information


Submitted
03 Oct 2019
Accepted
05 Nov 2019
First published
02 Dec 2019

This article is Open Access

Chem. Commun., 2019,55, 15129-15132
Article type
Communication

Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition

B. L. Patenall, G. T. Williams‡, L. Gwynne, L. J. Stephens, E. V. Lampard, H. J. Hathaway, N. T. Thet, A. E. Young, M. J. Sutton, R. D. Short, S. D. Bull, T. D. James, A. C. Sedgwick and A. T. A. Jenkins, Chem. Commun., 2019, 55, 15129
DOI: 10.1039/C9CC07759F

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