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Issue 94, 2019
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Determining isoleucine side-chain rotamer-sampling in proteins from 13C chemical shift

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Abstract

Chemical shifts are often the only nuclear magnetic resonance parameter that can be obtained for challenging macromolecular systems. Here we present a framework to derive the conformational sampling of isoleucine side chains from 13C chemical shifts and demonstrate that side-chain conformations in a low-populated folding intermediate can be determined.

Graphical abstract: Determining isoleucine side-chain rotamer-sampling in proteins from 13C chemical shift

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Publication details

The article was received on 21 Aug 2019, accepted on 14 Oct 2019 and first published on 15 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06496F
Chem. Commun., 2019,55, 14107-14110
  • Open access: Creative Commons BY license
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    Determining isoleucine side-chain rotamer-sampling in proteins from 13C chemical shift

    L. Siemons, B. Uluca-Yazgi, R. B. Pritchard, S. McCarthy, H. Heise and D. F. Hansen, Chem. Commun., 2019, 55, 14107
    DOI: 10.1039/C9CC06496F

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