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Issue 69, 2019
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A tumor microenvironment model coupled with a mass spectrometry system to probe the metabolism of drug-loaded nanoparticles

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Abstract

This study describes a novel integrated microfluidic platform with microvessel network channels which are connected to an electrospray ionization-mass spectrometer (ESI-MS), allowing real-time probing of nanoparticle (NP) drug delivery in vascular niche around tumors and understanding the drug delivery efficacy in a realistic tumor microenvironment.

Graphical abstract: A tumor microenvironment model coupled with a mass spectrometry system to probe the metabolism of drug-loaded nanoparticles

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Publication details

The article was received on 17 Jun 2019, accepted on 19 Jul 2019 and first published on 22 Jul 2019


Article type: Communication
DOI: 10.1039/C9CC04628C
Chem. Commun., 2019,55, 10218-10221

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    A tumor microenvironment model coupled with a mass spectrometry system to probe the metabolism of drug-loaded nanoparticles

    L. Lin, Y. Zheng, Z. Wu, W. Zhang and J. Lin, Chem. Commun., 2019, 55, 10218
    DOI: 10.1039/C9CC04628C

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