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Issue 35, 2019
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Organocatalytic enantioselective direct alkylation of phloroglucinol derivatives: asymmetric total synthesis of (+)-aflatoxin B2

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Abstract

The organocatalytic enantioselective Friedel–Crafts alkylation of phloroglucinol derivatives with enals is reported, providing general access to the benzylic chiral centers shown in a variety of phloroglucinol natural products. The synthetic utility is demonstrated by the very concise asymmetric total synthesis of aflatoxins B2.

Graphical abstract: Organocatalytic enantioselective direct alkylation of phloroglucinol derivatives: asymmetric total synthesis of (+)-aflatoxin B2

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Article information


Submitted
06 Mar 2019
Accepted
08 Apr 2019
First published
08 Apr 2019

Chem. Commun., 2019,55, 5171-5174
Article type
Communication

Organocatalytic enantioselective direct alkylation of phloroglucinol derivatives: asymmetric total synthesis of (+)-aflatoxin B2

Z. Wang and L. Zu, Chem. Commun., 2019, 55, 5171
DOI: 10.1039/C9CC01833F

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