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Issue 98, 2019
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A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8

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Abstract

Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations. 5 is suitable for nanoparticle functionalization and delivery to cancer cells, holding promise for diagnostic and/or therapeutic applications.

Graphical abstract: A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8

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Supplementary files

Article information


Submitted
31 Oct 2019
Accepted
08 Nov 2019
First published
22 Nov 2019

This article is Open Access

Chem. Commun., 2019,55, 14777-14780
Article type
Communication

A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8

F. Nardelli, M. Ghitti, G. Quilici, A. Gori, Q. Luo, A. Berardi, A. Sacchi, M. Monieri, G. Bergamaschi, W. Bermel, F. Chen, A. Corti, F. Curnis and G. Musco, Chem. Commun., 2019, 55, 14777
DOI: 10.1039/C9CC08518A

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