Issue 100, 2019

Reprogramming biological peptides to combat infectious diseases


With the rapid spread of resistance among parasites and bacterial pathogens, antibiotic-resistant infections have drawn much attention worldwide. Consequently, there is an urgent need to develop new strategies to treat neglected diseases and drug-resistant infections. Here, we outline several new strategies that have been developed to counter pathogenic microorganisms by designing and constructing antimicrobial peptides (AMPs). In addition to traditional discovery and design mechanisms guided by chemical biology, synthetic biology and computationally-based approaches offer useful tools for the discovery and generation of bioactive peptides. We believe that the convergence of such fields, coupled with systematic experimentation in animal models, will help translate biological peptides into the clinic. The future of anti-infective therapeutics is headed towards specifically designed molecules whose form is driven by computer-based frameworks. These molecules are selective, stable, and active at therapeutic doses.

Graphical abstract: Reprogramming biological peptides to combat infectious diseases

Article information

Article type
Feature Article
08 Oct 2019
25 Nov 2019
First published
25 Nov 2019
This article is Open Access
Creative Commons BY license

Chem. Commun., 2019,55, 15020-15032

Reprogramming biological peptides to combat infectious diseases

M. Der Torossian Torres and C. de la Fuente-Nunez, Chem. Commun., 2019, 55, 15020 DOI: 10.1039/C9CC07898C

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