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Issue 88, 2019
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Characterisation of three terpene synthases for β-barbatene, β-araneosene and nephthenol from social amoebae

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Abstract

The products of three terpene synthases from two social amoebae, Dictyostelium discoideum and Dictyostelium purpureum, were identified, showing sesquiterpene synthase activity for one and diterpene synthase activity for the other two enzymes. Site-directed mutagenesis experiments revealed the importance of a newly identfied highly conserved residue for catalytic activity. For one of the enzyme products, β-araneosene, a bromonium ion induced transannular cyclisation was investigated, yielding the first brominated derivatives of this diterpene.

Graphical abstract: Characterisation of three terpene synthases for β-barbatene, β-araneosene and nephthenol from social amoebae

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Article information


Submitted
30 Sep 2019
Accepted
11 Oct 2019
First published
11 Oct 2019

Chem. Commun., 2019,55, 13255-13258
Article type
Communication

Characterisation of three terpene synthases for β-barbatene, β-araneosene and nephthenol from social amoebae

J. Rinkel, T. G. Köllner, F. Chen and J. S. Dickschat, Chem. Commun., 2019, 55, 13255
DOI: 10.1039/C9CC07681F

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