Jump to main content
Jump to site search

Issue 90, 2019
Previous Article Next Article

ZnI2/Zn(OTf)2-TsOH: a versatile combined-acid system for catalytic intramolecular hydrofunctionalization and polyene cyclization

Author affiliations

Abstract

A mild and efficient combined-acid system using a zinc(II) salt [ZnI2 or Zn(OTf)2] and p-toluene sulfonic acid (TsOH) was investigated for catalytic cationic cyclizations, including intramolecular hydrocarboxylation, hydroalkoxylation, hydroamination, hydroamidation, hydroarylation and polyene cyclizations. This reaction provides easy access to five- and six-membered O- and N-containing saturated heterocyclic compounds, tetrahydronaphthalene derivatives and polycyclic skeletons in excellent yield with perfect Markovnikov selectivity and under mild conditions. The operational simplicity, broad applicability, and use of inexpensive commercially available catalysts make this protocol superior to existing methodologies.

Graphical abstract: ZnI2/Zn(OTf)2-TsOH: a versatile combined-acid system for catalytic intramolecular hydrofunctionalization and polyene cyclization

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Sep 2019, accepted on 17 Oct 2019 and first published on 17 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC07242J
Chem. Commun., 2019,55, 13522-13525

  •   Request permissions

    ZnI2/Zn(OTf)2-TsOH: a versatile combined-acid system for catalytic intramolecular hydrofunctionalization and polyene cyclization

    T. Chou, B. Yu and R. Chein, Chem. Commun., 2019, 55, 13522
    DOI: 10.1039/C9CC07242J

Search articles by author

Spotlight

Advertisements