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Issue 96, 2019
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Dynamic host–guest interaction enables autonomous single molecule blinking and super-resolution imaging

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Abstract

Synthetic host–guest complexes are inherently dynamic as they employ weak and reversible noncovalent interactions for their recognition processes. We strategically exploited dynamic supramolecular recognition between fluorescently labeled guest molecules to complementary cucurbit[7]uril hosts to obtain stochastic switching between fluorescence ON- and OFF-states, enabling PAINT-based nanoscopic imaging in cells and tissues.

Graphical abstract: Dynamic host–guest interaction enables autonomous single molecule blinking and super-resolution imaging

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Article information


Submitted
12 Sep 2019
Accepted
29 Oct 2019
First published
06 Nov 2019

Chem. Commun., 2019,55, 14430-14433
Article type
Communication

Dynamic host–guest interaction enables autonomous single molecule blinking and super-resolution imaging

R. Sasmal, N. Das Saha, F. Schueder, D. Joshi, V. Sheeba, R. Jungmann and S. S. Agasti, Chem. Commun., 2019, 55, 14430
DOI: 10.1039/C9CC07153A

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