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Issue 89, 2019
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Degradation of phthalic acid esters (PAEs) by an enzyme mimic and its application in the degradation of intracellular DEHP

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Abstract

Here, an enzyme mimic inspired by serine proteases was developed for the degradation of PAEs. This enzyme mimic, comprised an active site (SHD), a self-assembling polypeptide (LKLKLKL), a spacer (GGG) and a polymerizable site (DOPA) and showed high activity towards the degradation of DEHP in cells.

Graphical abstract: Degradation of phthalic acid esters (PAEs) by an enzyme mimic and its application in the degradation of intracellular DEHP

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Article information


Submitted
02 Sep 2019
Accepted
09 Oct 2019
First published
10 Oct 2019

Chem. Commun., 2019,55, 13458-13461
Article type
Communication

Degradation of phthalic acid esters (PAEs) by an enzyme mimic and its application in the degradation of intracellular DEHP

X. Li, J. Li, J. Zhu, S. Hao, G. Fang, J. Liu and S. Wang, Chem. Commun., 2019, 55, 13458
DOI: 10.1039/C9CC06794A

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