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Issue 74, 2019
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Determination of nucleobase-pairing free energies from rotamer equilibria of 2-(methylamino)pyrimidines

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Abstract

A fast straightforward method for the determination of free energies of modified nucleobase pairing is proposed. The method is based on the nuclear magnetic resonance (NMR) spectroscopy monitoring of conformational changes of 2-(methylamino)-pyrimidines upon intermolecular binding.

Graphical abstract: Determination of nucleobase-pairing free energies from rotamer equilibria of 2-(methylamino)pyrimidines

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Publication details

The article was received on 17 Jul 2019, accepted on 16 Aug 2019 and first published on 16 Aug 2019


Article type: Communication
DOI: 10.1039/C9CC05513D
Chem. Commun., 2019,55, 11075-11078

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    Determination of nucleobase-pairing free energies from rotamer equilibria of 2-(methylamino)pyrimidines

    J. R. Štoček, K. Bártová, L. Čechová, M. Šála, O. Socha, Z. Janeba and M. Dračínský, Chem. Commun., 2019, 55, 11075
    DOI: 10.1039/C9CC05513D

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