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Issue 62, 2019
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Inactivation of myostatin by photo-oxygenation using catalyst-functionalized peptides

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Abstract

Inhibition of myostatin is an attractive treatment for muscular dystrophy and other amyotrophic diseases. A myostatin-binding peptide was functionalized by equipped with an on/off switchable photo-oxygenation catalyst. This peptide induces a selective oxygenation of myostatin under near-infrared light, resulting in inactivation of myostatin. This peptide shows several orders of magnitude greater inhibitory effect than the original peptide.

Graphical abstract: Inactivation of myostatin by photo-oxygenation using catalyst-functionalized peptides

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Supplementary files

Article information


Submitted
07 Jun 2019
Accepted
28 Jun 2019
First published
04 Jul 2019

Chem. Commun., 2019,55, 9108-9111
Article type
Communication

Inactivation of myostatin by photo-oxygenation using catalyst-functionalized peptides

H. Okamoto, A. Taniguchi, S. Usami, A. Taguchi, K. Takayama and Y. Hayashi, Chem. Commun., 2019, 55, 9108
DOI: 10.1039/C9CC04368C

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