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Issue 63, 2019
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Umpolung cross-coupling of polyfluoroarenes with hydrazones via activation of C–F bonds

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Abstract

An umpolung strategy for the cross-coupling of polyfluoroarenes with various substituted hydrazones to construct C(sp2)–C(sp3) bonds is developed. In this strategy, the C–F bond of polyfluoroarenes is cleaved and coupled with moisture- and air-stable hydrazones under mild conditions with good to excellent yields. This method provides a useful tool for synthesizing polyfluorinated pharmaceuticals and functional materials.

Graphical abstract: Umpolung cross-coupling of polyfluoroarenes with hydrazones via activation of C–F bonds

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Supplementary files

Article information


Submitted
04 Jun 2019
Accepted
09 Jul 2019
First published
17 Jul 2019

Chem. Commun., 2019,55, 9323-9326
Article type
Communication

Umpolung cross-coupling of polyfluoroarenes with hydrazones via activation of C–F bonds

D. Cao, P. Pan, H. Zeng and C. Li, Chem. Commun., 2019, 55, 9323 DOI: 10.1039/C9CC04299G

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