Issue 61, 2019
From the journal:

Chemical Communications

A NIR light-triggered drug delivery system using core–shell gold nanostars–mesoporous silica nanoparticles based on multiphoton absorption photo-dissociation of 2-nitrobenzyl PEG†

Andy Hernández-Montoto,ab   Mónica Gorbe,abc   Antoni Llopis-Lorente, ORCID logo ab   José Manuel Terrés,a   Roberto Montes,a   Roberto Cao-Milán, ORCID logo d   Borja Díaz de Greñu,ab   María Alfonso,ab   Mar Orzaez,ce   María Dolores Marcos,abcf   Ramón Martínez-Máñez ORCID logo *abcf  and  Félix Sancenónabcf  

* Corresponding authors

a Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico, Universitat Politècnica de València, Universitat de València, Spain
E-mail: rmaez@qim.upv.es

b CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain

c Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina. Universitat Politècnica de València-Centro de Investigación Príncipe Felipe, Valencia, Spain

d Facultad de Química, Universidad de La Habana, 10400 La Habana, Cuba

e Centro de Investigación Príncipe Felipe, Laboratorio de Péptidos y Proteínas, Carrer d'Eduardo Primo Yúfera, 3, 46012 València, Spain

f Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain

Abstract

Gold nanostars coated with a mesoporous silica shell and functionalized with poly(ethylene glycol) containing photolabile 2-nitrobenzyl moieties are able to release doxorubicin after NIR light irradiation at low power irradiance via a multiphoton absorption photo-dissociation process.

Graphical abstract: A NIR light-triggered drug delivery system using core–shell gold nanostars–mesoporous silica nanoparticles based on multiphoton absorption photo-dissociation of 2-nitrobenzyl PEG

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Article information

DOI
https://doi.org/10.1039/C9CC04260A
Article type
Communication
Submitted
03 Jun 2019
Accepted
03 Jul 2019
First published
03 Jul 2019

Chem. Commun., 2019,55, 9039-9042

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A NIR light-triggered drug delivery system using core–shell gold nanostars–mesoporous silica nanoparticles based on multiphoton absorption photo-dissociation of 2-nitrobenzyl PEG

A. Hernández-Montoto, M. Gorbe, A. Llopis-Lorente, J. M. Terrés, R. Montes, R. Cao-Milán, B. Díaz de Greñu, M. Alfonso, M. Orzaez, M. D. Marcos, R. Martínez-Máñez and F. Sancenón, Chem. Commun., 2019, 55, 9039 DOI: 10.1039/C9CC04260A

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