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Issue 59, 2019
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Recent advances in the synthesis of axially chiral biaryls via transition metal-catalysed asymmetric C–H functionalization

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Abstract

Axially chiral biaryl motifs are widely present in natural products and pharmaceuticals. Moreover, they have been broadly used as privileged ligands in asymmetric catalysis. Over the past few decades, the efficient synthesis of axially chiral biaryls has been a research topic of great interest. This feature article will provide an overview of recent advances in the synthesis of these chiral skeletons via transition metal-catalysed asymmetric C–H functionalization.

Graphical abstract: Recent advances in the synthesis of axially chiral biaryls via transition metal-catalysed asymmetric C–H functionalization

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Article information


Submitted
22 May 2019
Accepted
26 Jun 2019
First published
27 Jun 2019

Chem. Commun., 2019,55, 8514-8523
Article type
Feature Article

Recent advances in the synthesis of axially chiral biaryls via transition metal-catalysed asymmetric C–H functionalization

G. Liao, T. Zhou, Q. Yao and B. Shi, Chem. Commun., 2019, 55, 8514
DOI: 10.1039/C9CC03967H

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