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Issue 58, 2019
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Cascade cyclization and acyl migration of propargylic esters with isocyanides: rapid access to substituted furans

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Abstract

A novel rearrangement of ester-activated propargylic acetate with isocyanide has been disclosed. This protocol enables a quick synthesis of polysubstituted furan derivatives. The reaction outcome also reveals that the ester group is employed for the construction of a furan ring and an acyl migration is observed.

Graphical abstract: Cascade cyclization and acyl migration of propargylic esters with isocyanides: rapid access to substituted furans

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Publication details

The article was received on 08 May 2019, accepted on 21 Jun 2019 and first published on 21 Jun 2019


Article type: Communication
DOI: 10.1039/C9CC03550H
Chem. Commun., 2019,55, 8394-8397

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    Cascade cyclization and acyl migration of propargylic esters with isocyanides: rapid access to substituted furans

    J. Hu, Y. Fei, H. Zhao, Z. Wang, C. Li and J. Li, Chem. Commun., 2019, 55, 8394
    DOI: 10.1039/C9CC03550H

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