Issue 58, 2019

Cascade cyclization and acyl migration of propargylic esters with isocyanides: rapid access to substituted furans

Abstract

A novel rearrangement of ester-activated propargylic acetate with isocyanide has been disclosed. This protocol enables a quick synthesis of polysubstituted furan derivatives. The reaction outcome also reveals that the ester group is employed for the construction of a furan ring and an acyl migration is observed.

Graphical abstract: Cascade cyclization and acyl migration of propargylic esters with isocyanides: rapid access to substituted furans

Supplementary files

Article information

Article type
Communication
Submitted
08 May 2019
Accepted
21 Jun 2019
First published
21 Jun 2019

Chem. Commun., 2019,55, 8394-8397

Cascade cyclization and acyl migration of propargylic esters with isocyanides: rapid access to substituted furans

J. Hu, Y. Fei, H. Zhao, Z. Wang, C. Li and J. Li, Chem. Commun., 2019, 55, 8394 DOI: 10.1039/C9CC03550H

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