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Issue 62, 2019
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Isothermal amplification of specific DNA molecules inside giant unilamellar vesicles

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Abstract

An isothermal amplification circuit for specific DNA molecules was implemented in giant unilamellar vesicles. Using this circuit, over 5000-fold amplification of output DNAs was achieved, and the amplification behaviour depended on the concentration of input signal DNAs in a cell-sized compartment. Moreover, initiation of the amplification by photo-stimulation was demonstrated.

Graphical abstract: Isothermal amplification of specific DNA molecules inside giant unilamellar vesicles

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Publication details

The article was received on 28 Apr 2019, accepted on 08 May 2019 and first published on 09 Jul 2019


Article type: Communication
DOI: 10.1039/C9CC03277K
Chem. Commun., 2019,55, 9084-9087
  • Open access: Creative Commons BY license
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    Isothermal amplification of specific DNA molecules inside giant unilamellar vesicles

    Y. Sato, K. Komiya, I. Kawamata, S. Murata and S. M. Nomura, Chem. Commun., 2019, 55, 9084
    DOI: 10.1039/C9CC03277K

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