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Issue 50, 2019
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A nanodrug to combat cisplatin-resistance by protecting cisplatin with p-sulfonatocalix[4]arene and regulating glutathione S-transferases with loaded 5-fluorouracil

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Abstract

A nanodrug that can effectively combat cisplatin-resistant A549/CDDP cells was developed by protecting cisplatin from glutathione (GSH) detoxification trough a host–guest interaction between cisplatin and p-sulfonatocalix[4]arene. The enzymatic activity of glutathione S-transferases (GSTs) was also regulated by loaded 5-fluorouracil (5-FU).

Graphical abstract: A nanodrug to combat cisplatin-resistance by protecting cisplatin with p-sulfonatocalix[4]arene and regulating glutathione S-transferases with loaded 5-fluorouracil

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Publication details

The article was received on 17 Apr 2019, accepted on 26 May 2019 and first published on 27 May 2019


Article type: Communication
DOI: 10.1039/C9CC03012C
Chem. Commun., 2019,55, 7199-7202

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    A nanodrug to combat cisplatin-resistance by protecting cisplatin with p-sulfonatocalix[4]arene and regulating glutathione S-transferases with loaded 5-fluorouracil

    X. Dai, X. Zhou, C. Liao, Y. Yao, Y. Yu and S. Zhang, Chem. Commun., 2019, 55, 7199
    DOI: 10.1039/C9CC03012C

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