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Issue 66, 2019
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Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in Chromobacterium violaceum

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Abstract

Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.

Graphical abstract: Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in Chromobacterium violaceum

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Supplementary files

Article information


Submitted
01 Apr 2019
Accepted
29 May 2019
First published
29 Jul 2019

This article is Open Access

Chem. Commun., 2019,55, 9765-9768
Article type
Communication

Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in Chromobacterium violaceum

J. Shepherd, T. Swift, C. Chang, J. R. Boyne, S. Rimmer and W. H. C. Martin, Chem. Commun., 2019, 55, 9765
DOI: 10.1039/C9CC02524C

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