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Issue 66, 2019
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Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in Chromobacterium violaceum

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Abstract

Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.

Graphical abstract: Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in Chromobacterium violaceum

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Publication details

The article was received on 01 Apr 2019, accepted on 29 May 2019 and first published on 29 Jul 2019


Article type: Communication
DOI: 10.1039/C9CC02524C
Chem. Commun., 2019,55, 9765-9768
  • Open access: Creative Commons BY license
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    Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in Chromobacterium violaceum

    J. Shepherd, T. Swift, C. Chang, J. R. Boyne, S. Rimmer and W. H. C. Martin, Chem. Commun., 2019, 55, 9765
    DOI: 10.1039/C9CC02524C

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