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Issue 44, 2019
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Photo-oxygenation inhibits tau amyloid formation

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Abstract

Tau amyloid formation and deposition are responsible for the onset of Alzheimer's disease. In particular, the seeding activity of the tau protein plays an important role in the spreading of tau pathology via its propagation in the human brain. Here we demonstrate that catalytic photo-oxygenation markedly suppresses tau seeding activity, resulting in the inhibition of amyloid formation, both in vitro and in cultured cells.

Graphical abstract: Photo-oxygenation inhibits tau amyloid formation

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Article information


Submitted
02 Mar 2019
Accepted
25 Apr 2019
First published
26 Apr 2019

Chem. Commun., 2019,55, 6165-6168
Article type
Communication

Photo-oxygenation inhibits tau amyloid formation

T. Suzuki, Y. Hori, T. Sawazaki, Y. Shimizu, Y. Nemoto, A. Taniguchi, S. Ozawa, Y. Sohma, M. Kanai and T. Tomita, Chem. Commun., 2019, 55, 6165
DOI: 10.1039/C9CC01728C

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