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Issue 31, 2019
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A nickel(ii)-catalyzed asymmetric intramolecular Alder-ene reaction of 1,7-dienes

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Abstract

A highly diastereo- and enantioselective intramolecular Alder-ene reaction with an alkene as the enophile has been developed by using a chiral N,N′-dioxide/nickel(II) complex as the catalyst. This protocol provides a facile route towards the synthesis of diverse 3,4-disubstituted chroman, tetrahydroquinoline, piperidine and thiochroman derivatives in high yields with good to excellent diastereo- and enantioselectivities.

Graphical abstract: A nickel(ii)-catalyzed asymmetric intramolecular Alder-ene reaction of 1,7-dienes

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Supplementary files

Article information


Submitted
22 Feb 2019
Accepted
19 Mar 2019
First published
19 Mar 2019

Chem. Commun., 2019,55, 4479-4482
Article type
Communication

A nickel(II)-catalyzed asymmetric intramolecular Alder-ene reaction of 1,7-dienes

W. Liu, P. Zhou, J. Lang, S. Dong, X. Liu and X. Feng, Chem. Commun., 2019, 55, 4479
DOI: 10.1039/C9CC01521C

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