Jump to main content
Jump to site search

Issue 31, 2019
Previous Article Next Article

Sydnone-based turn-on fluorogenic probes for no-wash protein labeling and in-cell imaging

Author affiliations

Abstract

We report the synthesis and use of sydnone-based profluorophores as tools for imaging applications. These new probes display exquisite reactivity towards strain promoted cycloaddition reactions with cycloalkynes allowing fast, efficient and selective labeling in biological media. Styryl-pyridinium sydnone probes were found particularly interesting for click reactions to proceed selectively inside cells.

Graphical abstract: Sydnone-based turn-on fluorogenic probes for no-wash protein labeling and in-cell imaging

Back to tab navigation

Supplementary files

Article information


Submitted
20 Feb 2019
Accepted
22 Mar 2019
First published
22 Mar 2019

Chem. Commun., 2019,55, 4582-4585
Article type
Communication

Sydnone-based turn-on fluorogenic probes for no-wash protein labeling and in-cell imaging

L. Plougastel, M. R. Pattanayak, M. Riomet, S. Bregant, A. Sallustrau, M. Nothisen, A. Wagner, D. Audisio and F. Taran, Chem. Commun., 2019, 55, 4582
DOI: 10.1039/C9CC01458F

Social activity

Search articles by author

Spotlight

Advertisements