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Issue 31, 2019
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Sydnone-based turn-on fluorogenic probes for no-wash protein labeling and in-cell imaging

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Abstract

We report the synthesis and use of sydnone-based profluorophores as tools for imaging applications. These new probes display exquisite reactivity towards strain promoted cycloaddition reactions with cycloalkynes allowing fast, efficient and selective labeling in biological media. Styryl-pyridinium sydnone probes were found particularly interesting for click reactions to proceed selectively inside cells.

Graphical abstract: Sydnone-based turn-on fluorogenic probes for no-wash protein labeling and in-cell imaging

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Publication details

The article was received on 20 Feb 2019, accepted on 22 Mar 2019 and first published on 22 Mar 2019


Article type: Communication
DOI: 10.1039/C9CC01458F
Chem. Commun., 2019,55, 4582-4585

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    Sydnone-based turn-on fluorogenic probes for no-wash protein labeling and in-cell imaging

    L. Plougastel, M. R. Pattanayak, M. Riomet, S. Bregant, A. Sallustrau, M. Nothisen, A. Wagner, D. Audisio and F. Taran, Chem. Commun., 2019, 55, 4582
    DOI: 10.1039/C9CC01458F

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