Jump to main content
Jump to site search

Issue 26, 2019
Previous Article Next Article

Base-mediated regioselective [3+2] annulation of ketenimines and isocyanides: efficient synthesis of 1,4,5-trisubstituted imidazoles

Author affiliations

Abstract

A novel base-mediated regioselective [3+2] annulation of active methylene isocyanides with ketenimines has been developed. In the presence of t-BuOK, a wide range of ketenimines readily react with active methylene isocyanides in DMF at 40 °C to afford 1,4,5-trisubstituted imidazoles efficiently.

Graphical abstract: Base-mediated regioselective [3+2] annulation of ketenimines and isocyanides: efficient synthesis of 1,4,5-trisubstituted imidazoles

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Feb 2019, accepted on 07 Mar 2019 and first published on 08 Mar 2019


Article type: Communication
DOI: 10.1039/C9CC01257E
Chem. Commun., 2019,55, 3821-3824

  •   Request permissions

    Base-mediated regioselective [3+2] annulation of ketenimines and isocyanides: efficient synthesis of 1,4,5-trisubstituted imidazoles

    J. Cai, H. Bai, Y. Wang, X. Xu, H. Xie and J. Liu, Chem. Commun., 2019, 55, 3821
    DOI: 10.1039/C9CC01257E

Search articles by author

Spotlight

Advertisements