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Issue 35, 2019
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USP7: combining tools towards selectivity

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Abstract

Active-site directed probes based on the ubiquitin scaffold have been successfully applied as tools to determine the levels of active deubiquitinating enzymes (DUBs). Here, we show the development of a Ub-based reagent selective for the DUB USP7. This concept can be applied for the generation of other new selective reagents.

Graphical abstract: USP7: combining tools towards selectivity

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Publication details

The article was received on 01 Feb 2019, accepted on 04 Mar 2019 and first published on 11 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC00969H
Chem. Commun., 2019,55, 5075-5078
  • Open access: Creative Commons BY-NC license
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    USP7: combining tools towards selectivity

    L. Gjonaj, A. Sapmaz, R. González-Prieto, A. C. O. Vertegaal, D. Flierman and H. Ovaa, Chem. Commun., 2019, 55, 5075
    DOI: 10.1039/C9CC00969H

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