Unique photoaffinity probes to study TGFβ signaling and receptor fates

D. Längle; F. Wesseler; D. Flötgen; H. Leek; A. T. Plowright; D. Schade

doi:10.1039/C9CC00929A

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Unique photoaffinity probes to study TGFβ signaling and receptor fates†

D. Längle,^ab F. Wesseler,^ab D. Flötgen,^b H. Leek,^c A. T. Plowright^d and D. Schade

*^ab

Author affiliations

* Corresponding authors

^a Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University Kiel, Gutenbergstr. 76, D-24118 Kiel, Germany
E-mail: schade@pharmazie.uni-kiel.de

^b Department of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Str. 4, D-44227 Dortmund, Germany

^c Early Product Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca Gothenburg, Mölndal SE-43183, Sweden

^d Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca Gothenburg, Mölndal SE-43183, Sweden

Abstract

A novel synthetic approach is used to prepare a diverse set of “first-in-class” dihydropyridine-based TGFβ receptor degraders bearing photoaffinity labels. These probes serve as valuable tools to study TGFβ receptor fates and dynamics – an important challenge in chemical biology.

Download options Please wait...

Supplementary files

Supplementary information PDF (6614K)

Article information

DOI: https://doi.org/10.1039/C9CC00929A
Article type: Communication
Submitted: 01 Feb 2019
Accepted: 14 Mar 2019
First published: 14 Mar 2019

Download Citation

Chem. Commun., 2019,55, 4323-4326

Permissions

Request permissions

Unique photoaffinity probes to study TGFβ signaling and receptor fates

D. Längle, F. Wesseler, D. Flötgen, H. Leek, A. T. Plowright and D. Schade, Chem. Commun., 2019, 55, 4323 DOI: 10.1039/C9CC00929A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Unique photoaffinity probes to study TGFβ signaling and receptor fates†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Unique photoaffinity probes to study TGFβ signaling and receptor fates

Social activity

Search articles by author

Spotlight

Advertisements