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Issue 30, 2019
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Unique photoaffinity probes to study TGFβ signaling and receptor fates

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Abstract

A novel synthetic approach is used to prepare a diverse set of “first-in-class” dihydropyridine-based TGFβ receptor degraders bearing photoaffinity labels. These probes serve as valuable tools to study TGFβ receptor fates and dynamics – an important challenge in chemical biology.

Graphical abstract: Unique photoaffinity probes to study TGFβ signaling and receptor fates

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Article information


Submitted
01 Feb 2019
Accepted
14 Mar 2019
First published
14 Mar 2019

Chem. Commun., 2019,55, 4323-4326
Article type
Communication

Unique photoaffinity probes to study TGFβ signaling and receptor fates

D. Längle, F. Wesseler, D. Flötgen, H. Leek, A. T. Plowright and D. Schade, Chem. Commun., 2019, 55, 4323
DOI: 10.1039/C9CC00929A

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