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Issue 30, 2019
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Prediction of ligand modulation patterns on membrane receptors via lysine reactivity profiling

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Abstract

Herein we provide a mass spectrometry-based lysine reactivity profiling strategy to monitor the ligand modulation of protein receptors, which is achieved by active dimethyl labeling of lysine residues and comparison of the alterations of labeling reactivity during ligand binding. The small-molecule ligand modulation patterns on the catechol-O-methyltransferase and the N-methyl-D-aspartate receptors have been predicted, including both binding regions and related conformational changes.

Graphical abstract: Prediction of ligand modulation patterns on membrane receptors via lysine reactivity profiling

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Publication details

The article was received on 21 Jan 2019, accepted on 21 Feb 2019 and first published on 22 Feb 2019


Article type: Communication
DOI: 10.1039/C9CC00520J
Chem. Commun., 2019,55, 4311-4314

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    Prediction of ligand modulation patterns on membrane receptors via lysine reactivity profiling

    Y. Zhou, Z. Liu, J. Zhang, T. Dou, J. Chen, G. Ge, S. Zhu and F. Wang, Chem. Commun., 2019, 55, 4311
    DOI: 10.1039/C9CC00520J

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