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Issue 26, 2019
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Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly

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Abstract

We report the synthesis of poly(2-ethyl-2-oxazoline)-based (PEtOx) nanoobjects by polymerization-induced self-assembly (PISA). First, well-defined PEtOx macromolecular chain transfer agents were synthesized by cationic ring-opening polymerization and click chemistry. The photoinitiated PISA of 2-hydroxypropyl methacrylate mediated by these PEtOx produced nanoobjects spanning the full range of core–shell morphologies. The nanoparticles exhibited high biocompatibility and stealth properties in vitro or in vivo, as well as thermoresponsive behavior.

Graphical abstract: Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly

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Publication details

The article was received on 16 Jan 2019, accepted on 21 Feb 2019 and first published on 25 Feb 2019


Article type: Communication
DOI: 10.1039/C9CC00407F
Chem. Commun., 2019,55, 3741-3744
  • Open access: Creative Commons BY-NC license
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    Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly

    D. Le, F. Wagner, M. Takamiya, I. Hsiao, G. Gil Alvaradejo, U. Strähle, C. Weiss and G. Delaittre, Chem. Commun., 2019, 55, 3741
    DOI: 10.1039/C9CC00407F

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