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Issue 42, 2019
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Efficient discovery of novel antimicrobials through integration of synthesis and testing in crude ribosome extract

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Abstract

By coupling in situ [2+3] Huisgen cycloaddition with an in vitro transcription/translation luminescence assay in a crude ribosomal extract, a robust and accurate high-throughput platform was successfully developed and applied for efficient identification of novel structural types of ribosomal inhibitors with antimicrobial activity against drug-resistant bacteria.

Graphical abstract: Efficient discovery of novel antimicrobials through integration of synthesis and testing in crude ribosome extract

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Publication details

The article was received on 07 Jan 2019, accepted on 13 Apr 2019 and first published on 15 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC00144A
Chem. Commun., 2019,55, 5886-5889

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    Efficient discovery of novel antimicrobials through integration of synthesis and testing in crude ribosome extract

    Z. Sang, Y. Lu, Y. Zhou, Y. Ju, Q. An, S. Shen, J. Shi, J. He, T. Yang and Y. Luo, Chem. Commun., 2019, 55, 5886
    DOI: 10.1039/C9CC00144A

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