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Issue 61, 2019
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A new strategy for the in vitro selection of stapled peptide inhibitors by mRNA display

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Abstract

Hydrocarbon stapled peptides are promising therapeutics for inhibition of intracellular protein–protein interactions. Here we develop a new high-throughput strategy for hydrocarbon stapled peptide discovery based on mRNA display of peptides containing α-methyl cysteine and cyclized with m-dibromoxylene. We focus on development of a peptide binder to the HPV16 E2 protein.

Graphical abstract: A new strategy for the in vitro selection of stapled peptide inhibitors by mRNA display

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Supplementary files

Article information


Submitted
24 Dec 2018
Accepted
06 Jun 2019
First published
10 Jul 2019

This article is Open Access

Chem. Commun., 2019,55, 8959-8962
Article type
Communication

A new strategy for the in vitro selection of stapled peptide inhibitors by mRNA display

E. S. Iqbal, S. L. Richardson, N. A. Abrigo, K. K. Dods, H. E. Osorio Franco, H. S. Gerrish, H. K. Kotapati, I. M. Morgan, D. S. Masterson and M. C. T. Hartman, Chem. Commun., 2019, 55, 8959
DOI: 10.1039/C8CC10192B

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