Highly enantioselective iridium catalyzed carbonyl (2-vinyl)allylation or “isoprenylation” is achieved via hydrogen auto-transfer or 2-propanol-mediated reductive coupling from primary alcohol or aldehyde reactants, respectively. Using this method, asymmetric total syntheses of the terpenoid natural products (+)-ipsenol and (+)-ipsdienol were achieved.
M. Xiang, G. Luo, Y. Wang and M. J. Krische, Chem. Commun., 2019, 55, 981 DOI: 10.1039/C8CC09706B
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