Jianwei Han, Yanxia Zhang, Xin-Yan Wu and Henry N. C. Wong
Chem. Commun., 2019,55, 397-400
DOI:
10.1039/C8CC09049A,
Communication
An excellent level of enantioselectivity in asymmetric sulfenylation of 4-substituted pyrazolones was achieved with chiral iminophosphorane as the organocatalyst under continuum solvation conditions (up to 99% ee). Importantly, this catalytic process features high efficiency with excellent enantioselectivities, easy separation of products, low catalytic loadings and scale-up to grams without loss of enantioselectivity.
