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Issue 10, 2019
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Trastuzumab gold-conjugates: synthetic approach and in vitro evaluation of anticancer activities in breast cancer cell lines

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Abstract

We describe the preparation of gold(I)-compounds that are amenable to efficient bioconjugation with monoclonal antibodies via activated ester or maleimide linkers. New Trastuzumab–gold conjugates were synthesized and fully characterized. These bioconjugates are significantly more cytotoxic (sub-micromolar range) to HER2-positive breast cancer cells than the gold complexes and Trastuzumab.

Graphical abstract: Trastuzumab gold-conjugates: synthetic approach and in vitro evaluation of anticancer activities in breast cancer cell lines

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Publication details

The article was received on 03 Nov 2018, accepted on 04 Jan 2019 and first published on 04 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC08769E
Chem. Commun., 2019,55, 1394-1397

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    Trastuzumab gold-conjugates: synthetic approach and in vitro evaluation of anticancer activities in breast cancer cell lines

    N. Curado, G. Dewaele-Le Roi, S. Poty, J. S. Lewis and M. Contel, Chem. Commun., 2019, 55, 1394
    DOI: 10.1039/C8CC08769E

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