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Issue 1, 2019
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A new class of supramolecular ligands stabilizes 14-3-3 protein–protein interactions by up to two orders of magnitude

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Abstract

We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.

Graphical abstract: A new class of supramolecular ligands stabilizes 14-3-3 protein–protein interactions by up to two orders of magnitude

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Submitted
04 Oct 2018
Accepted
26 Nov 2018
First published
26 Nov 2018

Chem. Commun., 2019,55, 111-114
Article type
Communication

A new class of supramolecular ligands stabilizes 14-3-3 protein–protein interactions by up to two orders of magnitude

A. Gigante, J.-N. Grad, J. Briels, M. Bartel, D. Hoffmann, C. Ottmann and C. Schmuck, Chem. Commun., 2019, 55, 111
DOI: 10.1039/C8CC07946C

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