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Issue 6, 2019
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A phototherapeutic fluorescent β-cyclodextrin branched polymer delivering nitric oxide

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Abstract

We report herein on a novel water-soluble β-cyclodextrin-branched polymer covalently integrating a fluorescein moiety and a nitric oxide (NO) photodonor within its macromolecular skeleton. Photoexcitation with visible light induces the parallel activation of the two chromophores, which results in the green fluorescence emission suitable for imaging accompanied by NO release for therapy. In fact, this polymer internalizes in squamous carcinoma cancer cells in vitro, visualized by fluorescence microscopy, and induces cell mortality as result of the NO photo-decaging. The non-covalent drug delivery capability of this new material is also demonstrated using a hydrophobic photosensitizer for photodynamic therapy as a probe.

Graphical abstract: A phototherapeutic fluorescent β-cyclodextrin branched polymer delivering nitric oxide

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Publication details

The article was received on 12 Mar 2019, accepted on 13 Apr 2019 and first published on 16 Apr 2019


Article type: Communication
DOI: 10.1039/C9BM00395A
Biomater. Sci., 2019,7, 2272-2276

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    A phototherapeutic fluorescent β-cyclodextrin branched polymer delivering nitric oxide

    M. Malanga, M. Seggio, V. Kirejev, A. Fraix, I. Di Bari, E. Fenyvesi, M. B. Ericson and S. Sortino, Biomater. Sci., 2019, 7, 2272
    DOI: 10.1039/C9BM00395A

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