Jump to main content
Jump to site search

Issue 7, 2019
Previous Article Next Article

An eximious and affordable GSH stimulus-responsive poly(α-lipoic acid) nanocarrier bonding combretastatin A4 for tumor therapy

Author affiliations

Abstract

Due to poor penetration of cytotoxic-drug-loaded-nanomedicines, more and more attention has been paid to nanodrugs of vascular disrupting agents (VDAs). However, traditional VDA nanodrugs lack tumor-selectivity, so new nano-carriers for tumor-selective CA4 delivery are urgently needed. Here, a novel PEGylated poly(alpha-lipoic acid) graft combretastatin A4 (PALA-g-mPEG/CA4) nanoparticle with glutathione (GSH) stimulus responsive ability was prepared from alpha-lipoic acid in a simple approach, which can accumulate and release CA4 selectively in a tumor site. Furthermore, this simple system has potential application value for tumor-targeting delivery and GSH sensitive release of other drugs.

Graphical abstract: An eximious and affordable GSH stimulus-responsive poly(α-lipoic acid) nanocarrier bonding combretastatin A4 for tumor therapy

Back to tab navigation

Publication details

The article was received on 02 Jan 2019, accepted on 01 Apr 2019 and first published on 07 May 2019


Article type: Paper
DOI: 10.1039/C9BM00002J
Biomater. Sci., 2019,7, 2803-2811

  •   Request permissions

    An eximious and affordable GSH stimulus-responsive poly(α-lipoic acid) nanocarrier bonding combretastatin A4 for tumor therapy

    Z. Liu, N. Shen, Z. Tang, D. Zhang, L. Ma, C. Yang and X. Chen, Biomater. Sci., 2019, 7, 2803
    DOI: 10.1039/C9BM00002J

Search articles by author

Spotlight

Advertisements