A novel fluorescent turn-on probe for imaging biothiols based on SNAr substitution-skeletal rearrangement strategy

Aishan Ren; Dongjian Zhu; Xing Zhong; Yuhao Xiong; Zhenhua Duan

doi:10.1039/C8AY02413H

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A novel fluorescent turn-on probe for imaging biothiols based on S_NAr substitution-skeletal rearrangement strategy†

Aishan Ren,^a Dongjian Zhu,

*^a Xing Zhong,^a Yuhao Xiong^a and Zhenhua Duan^a

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* Corresponding authors

^a Institute of Food Science and Engineering Technology, College of Food and Bioengineering, Hezhou University, Hezhou 542899, P. R. China
E-mail: zhudongjian@iccas.ac.cn

Abstract

A novel fluorescent turn-on probe 2 not only exhibited dramatic fluorescence enhancement by quinoline-to-quinolinone transformation, but also showed high sensitivity in the order Cys > GSH > Hcy. Importantly, 2 was successfully applied for imaging of biothiols in living cells.

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Article information

DOI: https://doi.org/10.1039/C8AY02413H
Article type: Communication
Submitted: 05 Nov 2018
Accepted: 19 Dec 2018
First published: 08 Jan 2019

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Anal. Methods, 2019,11, 262-267

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A novel fluorescent turn-on probe for imaging biothiols based on S_NAr substitution-skeletal rearrangement strategy

A. Ren, D. Zhu, X. Zhong, Y. Xiong and Z. Duan, Anal. Methods, 2019, 11, 262 DOI: 10.1039/C8AY02413H

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Analytical Methods