Nano-analytical characterization of endogenous minerals in healthy placental tissue: mineral distribution, composition and ultrastructure

Alexandre H. C. Anthis; Elena Tsolaki; Louis Didierlaurent; Samuel Staubli; Robert Zboray; Antonia Neels; Dörthe Dietrich; Pius Manser; Lotus May Desbiolles; Sebastian Leschka; Simon Wildermuth; Sandro Lehner; Pascale Chavatte-Palmer; Wolfram Jochum; Peter Wick; Alex Dommann; Tina Bürki-Turnherr; Tina Fischer; René Hornung; Sergio Bertazzo; Inge K. Herrmann

doi:10.1039/C9AN01312A

Nano-analytical characterization of endogenous minerals in healthy placental tissue: mineral distribution, composition and ultrastructure†

Alexandre H. C. Anthis,‡^ab Elena Tsolaki,‡^c Louis Didierlaurent,^a Samuel Staubli,^a Robert Zboray,^d Antonia Neels,

^d Dörthe Dietrich,^e Pius Manser,^a Lotus May Desbiolles,^f Sebastian Leschka,^f Simon Wildermuth,^f Sandro Lehner,^g Pascale Chavatte-Palmer,^h Wolfram Jochum,ⁱ Peter Wick,

^a Alex Dommann,^ad Tina Bürki-Turnherr,

^a Tina Fischer,^j René Hornung,^j Sergio Bertazzo §^c and Inge K. Herrmann

§*^ab

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* Corresponding authors

^a Laboratory for Particles Biology Interactions, Department Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), Lerchenfeldstrasse 5, CH-9014, St Gallen, Switzerland
E-mail: inge.herrmann@empa.ch

^b Nanoparticle Systems Engineering Laboratory, Institute of Process Engineering (IPE), Department of Mechanical and Process Engineering (D-MAVT), ETH Zurich, Sonneggstrasse 3, CH-8092, Zurich, Switzerland

^c Department of Medical Physics & Biomedical Engineering, University College London, London, UK

^d Center for X-ray Analytics, Department Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), Überlandstrasse 129, CH-8900, Dübendorf, Switzerland

^e Westfälische Wilhelms-Universität Münster, Institute of Inorganic and Analytical Chemistry, Corrensstraße 30, D-48149, Münster, Germany

^f Division of Radiology and Nuclear Medicine, Cantonal Hospital St Gallen (KSSG), Rorschacherstrasse 95, CH-9007, St Gallen, Switzerland

^g Laboratory for Advanced Fibers and Laboratory for Biointerfaces, Department Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), Lerchenfeldstrasse 5, CH-9014, St Gallen, Switzerland

^h UMR BDR, INRA, ENVA, Université Paris Saclay, F-78350, Jouy en Josas, France

ⁱ Institute of Pathology, Cantonal Hospital St Gallen (KSSG), Rorschacherstrasse 95, CH-9007, St Gallen, Switzerland

^j Department of Gynaecology, Cantonal Hospital St Gallen (KSSG), Rorschacherstrasse 95, CH-9007, St Gallen, Switzerland

Abstract

Despite its crucial role, the placenta is the least understood human organ. Recent clinical studies indicate a direct association between placental calcification and maternal and offspring health. This study reveals distinct characteristics of minerals formed during gestational ageing using cutting-edge nano-analytical characterization and paves the way for investigations focused on the identification of potential markers for disease risks in a clinical setting based on atypical placental mineral fingerprints.

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Nano-analytical characterization of endogenous minerals in healthy placental tissue: mineral distribution, composition and ultrastructure†

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