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Issue 24, 2019
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Reliable, high-quality suppression of NMR signals arising from water and macromolecules: application to bio-fluid analysis

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Abstract

Analysis of metabolites in biofluids using nuclear magnetic resonance often requires the suppression of obscuring signals arising from water and macromolecules. This paper analyses the limitations of the pulse sequence most commonly used to achieve such suppression (presat-CPMG) and proposes new pulse sequences that do not share those limitations. The utility of these improved pulse sequences is demonstrated in a metabolomic study of multiple sclerosis (MS) patients.

Graphical abstract: Reliable, high-quality suppression of NMR signals arising from water and macromolecules: application to bio-fluid analysis

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Article information


Submitted
31 May 2019
Accepted
15 Oct 2019
First published
06 Nov 2019

Analyst, 2019,144, 7270-7277
Article type
Paper

Reliable, high-quality suppression of NMR signals arising from water and macromolecules: application to bio-fluid analysis

J. A. Aguilar, J. Cassani, F. Probert, J. Palace, T. D. W. Claridge, A. Botana and A. M. Kenwright, Analyst, 2019, 144, 7270
DOI: 10.1039/C9AN01005J

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