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Issue 2, 2019
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A DNA minimachine for selective and sensitive detection of DNA

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Abstract

Synthetic molecular machines have been explored to manipulate matter at the molecular level. Here, we designed a multifunctional DNA nano-construct, dubbed a ‘DNA minimachine’ (DMM), which (i) tightly binds complementary DNA; (ii) recognizes specific fragments with high selectivity and (iii) amplifies output signals. DMM1 detects lower concentrations of both single-stranded DNA and double-stranded DNA compared to a conventional probe. This study sets a direction towards the development of molecular machines for selective, sensitive and cost-efficient DNA analysis.

Graphical abstract: A DNA minimachine for selective and sensitive detection of DNA

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Article information


Submitted
23 Nov 2018
Accepted
05 Dec 2018
First published
07 Dec 2018

Analyst, 2019,144, 416-420
Article type
Communication
Author version available

A DNA minimachine for selective and sensitive detection of DNA

T. A. Lyalina, E. A. Goncharova, N. Y. Prokofeva, E. S. Voroshilina and D. M. Kolpashchikov, Analyst, 2019, 144, 416
DOI: 10.1039/C8AN02274G

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