Issue 2, 2019

A DNA minimachine for selective and sensitive detection of DNA

Abstract

Synthetic molecular machines have been explored to manipulate matter at the molecular level. Here, we designed a multifunctional DNA nano-construct, dubbed a ‘DNA minimachine’ (DMM), which (i) tightly binds complementary DNA; (ii) recognizes specific fragments with high selectivity and (iii) amplifies output signals. DMM1 detects lower concentrations of both single-stranded DNA and double-stranded DNA compared to a conventional probe. This study sets a direction towards the development of molecular machines for selective, sensitive and cost-efficient DNA analysis.

Graphical abstract: A DNA minimachine for selective and sensitive detection of DNA

Supplementary files

Article information

Article type
Communication
Submitted
23 Nov 2018
Accepted
05 Dec 2018
First published
07 Dec 2018

Analyst, 2019,144, 416-420

Author version available

A DNA minimachine for selective and sensitive detection of DNA

T. A. Lyalina, E. A. Goncharova, N. Y. Prokofeva, E. S. Voroshilina and D. M. Kolpashchikov, Analyst, 2019, 144, 416 DOI: 10.1039/C8AN02274G

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