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Issue 10, 2019
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Reaction-based fluorometric analysis of N-bromosuccinimide by oxidative deprotection of dithiane

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Abstract

In this study, a fluorescent probe is developed for the first time for N-bromosuccinimide (NBS), a synthetically and analytically important compound. Pyrene–dithiane-based probe 1 showed prominently selective and sensitive signaling behavior toward NBS owing to the oxidative cleavage of the dithiane protecting group of 1-pyrenecarboxaldehyde. The NBS-selective signaling of the probe was possible under competitive conditions in the presence of common metal ions and anions as a background. The detection limit of the probe for NBS was found to be 5.6 × 10−8 M (10.0 ppb). The signaling product was sufficiently stable under the oxidative stress of NBS in contrast to another tested compound, 6-methoxy-2-naphthaldehyde-based dithiane derivative 2, which showed a gradually decaying response because of the reaction of the signaling product with the residual NBS. In the practical application of the probe, a smartphone was used as a stand-alone device, and the fluorometric assays of the commercial NBS reagents could be conducted rapidly and in a convenient manner.

Graphical abstract: Reaction-based fluorometric analysis of N-bromosuccinimide by oxidative deprotection of dithiane

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Publication details

The article was received on 04 Nov 2018, accepted on 05 Apr 2019 and first published on 06 Apr 2019


Article type: Paper
DOI: 10.1039/C8AN02125B
Analyst, 2019,144, 3267-3273

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    Reaction-based fluorometric analysis of N-bromosuccinimide by oxidative deprotection of dithiane

    Y. J. Lee, M. G. Choi, T. J. Park and S. Chang, Analyst, 2019, 144, 3267
    DOI: 10.1039/C8AN02125B

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