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Issue 2, 2019
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Visual detection of cancer cells by using in situ grown functional Cu2−xSe/reduced graphene oxide hybrids acting as an efficient nanozyme

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Abstract

A simple protocol for in situ growth of Cu2−xSe nanoparticles on graphene oxide hybrids (Cu2−xSe/rGO) acting as an efficient nanozyme is developed and thus a sensitive visual detection method of cancer cells is proposed. The Cu2−xSe/rGO heterogeneous nanomaterials have been proven to exhibit high peroxidase-like activity to catalyze the reaction of the peroxidase substrate in the presence of hydrogen peroxide. Herein, we used Cu2−xSe/rGO as a signal transducer to develop a colorimetric assay for the direct detection of cancer cells and a total of 63 cancer cells (MCF-7) can be distinguished by naked-eye observation. The results showed that the Cu2−xSe/rGO hybrids could be the promising nanozyme mimetics for potential applications in bioanalytical fields.

Graphical abstract: Visual detection of cancer cells by using in situ grown functional Cu2−xSe/reduced graphene oxide hybrids acting as an efficient nanozyme

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Supplementary files

Article information


Submitted
25 Sep 2018
Accepted
06 Nov 2018
First published
07 Nov 2018

Analyst, 2019,144, 716-721
Article type
Paper

Visual detection of cancer cells by using in situ grown functional Cu2−xSe/reduced graphene oxide hybrids acting as an efficient nanozyme

Q. J. Guo, Z. Y. Pan, C. Men, W. Y. Lv, H. Y. Zou and C. Z. Huang, Analyst, 2019, 144, 716
DOI: 10.1039/C8AN01849A

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